Oxidation leads to the production of free radicals resulting in a chain reaction that causes damage to living organisms. Taken together, these data suggest that GliSODin® could be used for the management of asthma symptoms.Īntioxidants quench reactive oxygen species ( 1) however, their levels decrease with age, causing a corresponding increase in oxidative stress ( 2– 4). Moreover, adoptively transferred CD4+ T cells from asthmatic mice exhibited a reduced reactivation of Th2 and Th17 cells following stimulation with HDM plus GliSODin®.Ĭonclusion: GliSODin® abrogates asthma features and reduces CD4+ T-cell polarization and reactivation.

Coculturing CD4+ T-cell with HDM-sensitized dendritic cells and GliSODin® reduced T-cell polarization into Th2 and Th17 cells.

Results: GliSODin® reduced airway hyperresponsiveness, lung innate and adaptive immune response, and HDM-specific IgE production. Methods: House dust mite (HDM)-induced asthmatic mice were orally exposed to GliSODin®, and airway hyperresponsiveness, lung inflammation, in vitro T-cell polarization, in vivo T-cell reactivation, and blood immunoglobulin were investigated. Objectives: In this study, we evaluated the efficacy and mechanism of action GliSODin® in the treatment of allergic asthma. Melon SOD-gliadin, which is known as GliSODin®, is commonly used as a nutritional supplement that has proven antioxidant properties. Superoxide dismutases (SODs) are enzymes that constitute the first line of defense against ROS. 4INRAE, Biopolymères Intéractions Assemblages (BIA), Nantes, Franceīackground: Asthma is a chronic inflammatory airway disease characterized by a prevailing type 2 inflammation, airway hyperresponsiveness, and mucus hypersecretion and is driven by various factors among which oxidative molecules, called reactive oxygen species (ROS), play a major role.2Université de Nantes, CNRS, INSERM, l’institut du thorax, Nantes, France.1Institut Universitaire de Cardiologie et de Pneumologie de Québec, Département de Médecine, Université Laval, Québec, QC, Canada.Martin Klein 1, Eleonore Dijoux 2, Marie-Aude Cheminant 2, Laurent Intes 3 and Grégory Bouchaud 4*

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